ELECTROMAGNETIC INDUCTION DEVICE AND METHOD FOR ACTIVATING A TARGET TISSUE

专利摘要:
it is an electromagnetic induction device (2) to activate a target tissue in a human or animal body through its muscular or neural system comprising: (i) an electromagnetic field generator (21) with a coil design (211) configured to generate an electromagnetic field (212) having a desired shape (213), (ii) a mounting arrangement (22) that maintains the coil design (211) of the electromagnetic field generator (21 ) in the body of a human or animal, (iii) a sensor member (4) configured to detect an activation of the target tissue, (iv) an electromagnetic field adjustment mechanism (21) configured to automatically adjust the position of the electromagnetic field (212) generated by the coil design (211) and adjusting a field strength of the electromagnetic field (212) generated by the coil design, and (v) a calibration unit (31) in communication with the sensor member (4) and with the electromagnetic field adjustment mechanism (2 1). the calibration unit (31) is configured (a) to control the electromagnetic field adjustment mechanism (21) to automatically vary the position of the electromagnetic field (212) generated by the coil design (211) and automatically vary the field strength the electromagnetic field (212) generated by the coil design, (b) to receive an activation feedback signal from the sensor member (4) upon detection of target tissue activation, and (c) to control the activation mechanism electromagnetic field adjustment (21) to automatically stop the variation of the position of the electromagnetic field (212) generated by the coil design (211) when the activation feedback signal is received and automatically stop the variation of the field strength of the electromagnetic field ( 212) generated by the coil design (211) when the activation feedback is received.
公开号:BR112020015997A2
申请号:R112020015997-2
申请日:2019-02-06
公开日:2020-12-15
发明作者:Ronja Müller-Bruhn
申请人:Stimit Ag；
IPC主号:

专利说明:

[001] [001] The present invention relates to an electromagnetic induction device according to the preamble of independent claim 1 and, more particularly, to a process for manufacturing that device, a method for activating a target tissue and uses of that device. TECHNICAL FUNDAMENTALS
[002] [002] In medicine, it is known that for many purposes it is beneficial to activate a target tissue of a patient. For example, in intensive care units in hospitals, it may be desired to activate the diaphragm of ventilated patients in order to avoid adverse effects resulting from diaphragm disuse. It has been shown that atrophy due to disuse of muscle fibers in the diaphragm occurs in the first 18 to 69 hours of mechanical ventilation, and the cross-sections of muscle fibers decreased by more than 50% in this period. Therefore, the aim is to activate the diaphragm repeatedly while the patient is on artificial or mechanical breathing so that the diaphragm function can be maintained, or to activate the diaphragm at least during the weaning period to support the effective restoration of independent respiratory function.
[003] [003] To achieve this activation of tissues in a patient's body, it is known to directly stimulate the tissue or to indirectly activate the tissue by stimulating specific parts of the neural system. For example, the target tissue being a muscle tissue can be activated by providing electrical pulses directly to the tissue or to the nerves associated with the tissue. More specifically, it is known that the diaphragm can be activated by stimulating the phrenic nerve, for example, in the patient's neck.
[004] [004] In this context, the document US 2016/0310730 A1 describes an apparatus to reduce the disuse of the diaphragm induced by ventilation in a patient who receives ventilation support from a mechanical ventilator (MV). The apparatus includes a first and second type electrode array and comprises a plurality of electrodes configured to stimulate a patient's phrenic nerve, and at least one controller that identifies one type of electrode array from at least two different types, and generate a stimulus signal to stimulate a patient's phrenic nerve based on the electrode type identity. This electrode-based stimulus is not very robust to patient movements or relocations, and the possible depth of stimulus can be significantly limited by bones or adipose tissue. Additionally, the electrode stimulus is reported to be more painful to the patient than the electromagnetic stimulus.
[005] [005] Therefore, there is a need for a system that allows a more convenient and efficient operation, as well as reducing the side effects in the stimulus. DISCLOSURE OF THE INVENTION
[006] [006] According to the invention, this need is solved by an electromagnetic induction device as defined by the resources of independent claim 1, by a process for manufacturing an electromagnetic induction device as defined by the resources of independent claim 27, by a a method for activating a target tissue in the body of a human or animal as defined by the resources of independent claim 51, and for uses as defined by the resources of independent claims 67 to 69. Preferred modalities are matters of dependent claims.
[007] [007] In one aspect, the invention consists of an electromagnetic induction device to activate a target tissue in the body of a human or animal through its muscular or neural system, the device comprising (i) a generator of electromagnetic field with coil design configured to generate a spatial electromagnetic field having a desired shape, (ii) a mounting arrangement that maintains the coil design of the electromagnetic field generator in the body of a human or animal, (iii) a sensor member configured to detect an activation of the target tissue, (iv) an electromagnetic field adjustment mechanism configured to automatically adjust the position of the electromagnetic field generated by the coil design, and (v) a calibration unit in communication with the sensor member and with the electromagnetic field adjustment mechanism. The coil design described in this document can be, or comprise, at least two coils or at least one coil with conical shape, or otherwise curved or expanded, or at least one small coil, that is, a coil sufficiently small to generate an expressive electromagnetic field such as a coil having a diameter of 3 cm or less. The desired shape of the electromagnetic field described in this document can comprise a peak formed by the spatial electromagnetic field.
[008] [008] Thus, tissue can refer to any type of human tissue, including, without limitation, skin or muscle tissue (that is, muscle fibers of the diaphragm).
[009] [009] The parameters of the voltage or current waveform applied to the coil by a generator affect the temporal characteristics of the electromagnetic field, including pulse shape, amplitude, width, polarity, and repetition frequency; duration and interval between bursts or pulse trains; total number of pulses; and interval between stimulus sessions and total number of sessions having, among other things, an influence on field intensity and determining whether and with what intensity or “dose” a target area or target tissue can be activated. The electromagnetic field can be generated by the electromagnetic field generator in single pulses or like a train. In this way, single pulses refer to the generation of the electromagnetic field for a comparatively short time and with a comparatively long interruption between two subsequent pulses.
[010] [010] The temporal characteristics and spatial distribution of the electromagnetic field can be tuned so that the desired activation (activation feedback) of the target area is achieved. In this way, activation feedback (signal) refers to a signal that indicates appropriate target tissue activation characteristics, for example, a signal that reaches or exceeds a target value (threshold), a signal that exhibits a certain pattern or shape curve, a signal that satisfies a certain algorithm known to represent an appropriate target tissue activation at the desired resistance, or any combination thereof. Activation feedback (signal) can comprise feedback in particular about a desired muscle activation resistance that must be achieved before the adjustment mechanism stops the variation. The appropriate signal characteristics of activation feedback can, for example, be defined by a user through an input interface or be detected by algorithms.
[011] [011] The calibration unit of the electromagnetic induction device according to the invention is configured (a) to control the electromagnetic field adjustment mechanism to automatically vary the position of the electromagnetic field generated by the coil design, (b) to receive an activation feedback signal from the sensor member upon detection of target tissue activation, and (c) to control the electromagnetic field adjustment mechanism to automatically stop the variation in the position of the electromagnetic field generated by the coil design when the activation feedback signal is received. Automatically stop position variation and eventually the field strength of the electromagnetic field allows a comparatively fast and accurate provision of the electromagnetic field for efficient and accurate activation of the target tissue. Likewise, any unintended variation in the configuration of the electromagnetic field can be avoided after finding the appropriate position. Field strength can also be referred to as the magnitude of the electromagnetic field.
[012] [012] The target tissue can be, or comprise, any muscle, muscle structure or section thereof that can be activated through the neural system.
[013] [013] The mounting arrangement can be incorporated to maintain the coil design of the electromagnetic field generator in a specific target position on the body of a human or animal. In particular, that target position can be a position in which a targeted portion of the neural system can be reached by the electromagnetic field created by the coils. The term “keep on” as used in connection with the mounting arrangement can refer to the coil design being in contact with or near the body. The position and orientation of the coil design can therefore be predefined or different.
[014] [014] The term “in communication” as used in connection with the calibration unit can refer to any connection of elements that allows communication, such as transferring or exchanging, information or data. The elements can be in communication whether wired or wireless to each other.
[015] [015] By configuring the calibration unit according to the invention, the electromagnetic field generator can be automatically oriented and adjusted, that is, calibrated, so that the neural system is stimulated to specifically activate the target tissue. In particular, the resistance of the electromagnetic field created and the orientation of its desired shape can be automatically varied until the neural system is stimulated so that the sensor receives a signal from the target tissue being activated. In this configuration, the neural system is specifically stimulated due to the desired shape of the electromagnetic field, side effects such as stimulating other portions of the neural system can be reduced or minimized. In addition, the system can react to the patient's movements, and automatically redirect towards the new target nerve location. In this way, the calibration unit, the electromagnetic field adjustment mechanism and the sensor member can form an automated feedback system implemented in the electromagnetic induction device.
[016] [016] Similarly, the electromagnetic induction device according to the invention allows automatic, convenient and efficient operation and, more particularly, for a simple, precise and specific location of the portion of the neural system to be stimulated to activate the tissue target. By automatically calibrating the device, considerable superior accuracy can be achieved compared to manually locating the relevant portion of the neural system, and usability can be improved. In addition, the device reduces side effects in stimulating the neural system.
[017] [017] Preferably, the mounting arrangement comprises a repositioning structure configured to automatically change a position of the coil design of the electromagnetic field generator in relation to the body of a human or animal when it is kept in the body of a being human or animal. The term "position" as used in connection with automatic alteration by the repositioning structure can refer to a location, orientation, shape conformation, or the like, and combinations thereof. The position can be changed by tilting, shifting, relocating, reshaping or similar actions.
[018] [018] Thus, the electromagnetic field adjustment mechanism preferably comprises the repositioning structure of the mounting arrangement and the calibration unit is preferably configured to automatically vary the position of the electromagnetic field by inducing the structure repositioning to automatically change the position of at least two electromagnetic coils in relation to the body of a human or animal. The repositioning structure of the mounting arrangement preferably comprises a tilt mechanism such as a joint configured to tilt the coil design of the electromagnetic field generator in relation to the body of a human or animal when held in the body. of a human being or an animal.
[019] [019] Alternatively or in addition, the electromagnetic field generator preferably comprises a repositionable conductive element located in the electromagnetic field generated by the coil design. This conductive element allows for an efficient alternative adjustment of the electromagnetic field.
[020] [020] In this way, the electromagnetic field adjustment mechanism preferably comprises the conductive element of the electromagnetic field generator and the calibration unit is preferably configured to automatically vary the position of the electromagnetic field by inducing the mechanism of electromagnetic field adjustment to automatically reposition the conductive element in the electromagnetic field. The conductor element preferably comprises a conductor axis. This axis can be a simple and efficient way to precisely adjust the electromagnetic field or its desired shape. In this context, the term "axle" can refer to any suitable rod-like structure such as a bar, rod, rod, pole, pole, or the like.
[021] [021] Preferably, the electromagnetic field generator comprises a coil arrangement including the coil design. In particular, the arrangement may consist of three or more coils. This arrangement allows the electromagnetic field to be formatted and moved in a more sophisticated way and, particularly, its desired shape.
[022] [022] Thus, the electromagnetic field adjustment mechanism preferably comprises the coil arrangement of the electromagnetic field generator and the calibration unit is preferably configured to automatically vary the position of the electromagnetic field by inducing the electromagnetic field adjustment mechanism to automatically enable different coil combinations of the coil arrangement. Preferably, the coils in the coil arrangement overlap. Preferably, the coil arrangement of the electromagnetic field generator is arranged to generate a plurality of electromagnetic fields each having a desired shape, the coil arrangement being arranged so that the plurality of electromagnetic fields overlap and generate an intensity accumulated. With this accumulated intensity, a more precise, well-defined and locally constrained electric field can be generated so that the neural system can be precisely stimulated.
[023] [023] Preferably, the sensor member comprises at least one electrode configured to be attached to the body of a human or animal so as to capture an activity from the target tissue. This electrode can efficiently detect the activation of the target tissue so that the calibration process can be interrupted and / or the proper functioning of the activation can be monitored.
[024] [024] Additionally or alternatively, the sensor member preferably comprises a flow sensor having an adapter connectable to a respiratory system in the body of a human or animal, the flow sensor being configured to detect a airflow change induced by target tissue activity. The term “flow sensor” according to the use in question refers to any device that allows the detection of an air movement and, in particular, an alteration of the air movement resulting in a pressure change.
[025] [025] In this way, the flow sensor adapter of the sensor member is preferably configured to be connected to a mouth and / or a nose on the body of a human or animal. The term “connected” according to the use in question refers to any direct connection or indirect connection through another element.
[026] [026] In addition or alternatively, the sensor member preferably comprises accelerators and / or gyroscopes and / or tension meters, in the patient's chest to detect contractions and the diaphragm. Likewise, an esophageal catheter or other types of catheters can be used as a sensor member to detect activation of the diaphragm. A catheter for measuring composite muscle action potentials (CMAP) of the diaphragm can be used as a sensor member. A catheter in the esophagus that measures the electrical activity of the diaphragm can be used as a sensor member. An EMG measurement of the diaphragm using a catheter can be used. A transdiaphragmatic pressure sensor as a catheter can be used as a sensor member, which measures gastric pressure (Pga) and esophageal pressure (Pes), sensor type: balloon catheter and pressure transducer, requires the replacement of small balloon-tipped catheters in the esophagus and stomach to assess intrathoracic and intra-abdominal pressures, respectively. Or, you can use ultrasound monitoring as a sensor member to detect diaphragm activations. In addition, oximetry measurements can be used as indicators of diaphragm inhalation / activation activities. Likewise, elastic bands / straps (around the chest or other expanding structures) can be used as a sensor member to detect activations of the diaphragm; cross-sectional changes in bands / straps can serve as indicators for muscle / diaphragm contractions. Electrodes on target muscles / diaphragms to measure action potentials (eg, electroencephalograms) can be used as a sensor member to detect diaphragm activation. For example, a cutaneous EMG measurement of the diaphragm can be used as a sensor member, so a diaphragmatic EMG is monitored with a superficial electrode positioned between the seventh and ninth intercostal spaces in the anterior axillary line.
[027] [027] Preferably, the mounting arrangement is configured to maintain the coil design on the neck of the body of a human or animal so that a phrenic nerve in the neural system of the body of a human or animal can be reached by the electromagnetic field generated by the coil design of the electromagnetic field generator. This modality allows you to efficiently stimulate the phrenic nerve and activate the diaphragm.
[028] [028] In this way, the mounting arrangement preferably comprises an arc member capable of being placed at a distance around the neck of the body of a human or animal, the two coils of the electromagnetic field generator being maintained in the arc member of the mounting arrangement. The coil design can be movable along the arc member. Or, the arc member can be equipped with the coil arrangement. This arc member provides comparatively high flexibility in relocating the coils and / or the electromagnetic field. Preferably, the arch member is equipped with an access passage. The passage can be incorporated as a recess, slit, through hole, or the like. This passage allows the body of a human or animal to be accessed particularly in an area where the electromagnetic field is applied. Similarly, for example, a catheter can be placed in an area of the neck where the phrenic nerve is stimulated.
[029] [029] Preferably, the electromagnetic induction device comprises a tracker configured to detect movement of the body of a human or animal in relation to the coil design of the electromagnetic field generator and to automatically change the position of the electromagnetic field to compensate for the detected movement of the body of a human or animal in relation to the coil design of the electromagnetic field generator. This arrangement allows to guarantee an appropriate operation even in cases where the body moves to a certain extent.
[030] [030] Preferably, the electromagnetic field adjustment mechanism is configured to automatically adjust a field strength of the electromagnetic field generated by the coil design and the calibration unit is configured to control the electromagnetic field adjustment mechanism to automatically vary the field strength of the electromagnetic field generated by the coil design and control the electromagnetic field adjustment mechanism to automatically stop the variation of the field strength of the electromagnetic field generated by the coil design when activation feedback is received. This arrangement allows you to efficiently adjust and size the electromagnetic field or its desired shape in order to achieve an appropriate simulation.
[031] [031] Preferably, the electromagnetic field adjustment mechanism is configured to automatically adjust the temporal characteristics of the electromagnetic field and the calibration unit is configured to control the electromagnetic field adjustment mechanism to automatically vary the temporal characteristics of the electromagnetic field and , optionally, control the electromagnetic field adjustment mechanism to automatically stop the variation of the temporal characteristics of the electromagnetic field generated by the coil design when the activation feedback is received.
[032] [032] Thus, the electromagnetic induction device preferably comprises an alarm unit, in which the tracker is connected to the alarm unit and configured to activate the alarm unit when the detected movement exceeds an attainable compensation range by changing -the position of the electromagnetic field generated by the two coils through the electromagnetic field adjustment mechanism. The alarm can be an acoustic, visual or tactile signal, or any combination thereof.
[033] [033] Preferably, the electromagnetic field generator is further configured to automatically adjust the transient field characteristics, for example, pulse shape, pulse duration, pulse frequency, inter-train intervals, etc. of the electromagnetic field generated by the coil design and the calibration unit is configured to control the electromagnetic field adjustment mechanism to automatically vary the transient field characteristics of the electromagnetic field generated by the coil design and to control the electromagnetic field generator to stop automatically the variation of the transient field characteristics of the electromagnetic field generated by the coil design when activation feedback is received.
[034] [034] Preferably, the sensor member comprises a pressure sensor having an adapter connectable to a respiratory system in the body of a human or animal, the pressure sensor being configured to detect a pressure change induced by a target tissue activity. The pressure sensor adapter of the sensor member can be configured to be connected to a mouth and / or nose of the body of a human or animal. The pressure sensor can be integral with the electromagnetic induction device, for example, in a unit. The same can also be understood in another unit as an associated ventilation machine, or the like. This arrangement allows detection of an activation of the target tissue resulting in a patient's breathing.
[035] [035] The electromagnetic induction device according to the invention and its preferred modalities can be advantageously used for transcutaneous electromagnetic induction of a phrenic nerve for a diagnostic purpose to assess the function of the diaphragm, or sleep apnea, or other forms of breathing for sleep disorders.
[036] [036] Or, the electromagnetic induction device according to the invention and its preferred modalities can be advantageously used for regular repetitive transcutaneous electromagnetic induction of a phrenic nerve for therapeutic use in patients without spontaneous breathing, for example, for resuscitation and keeping alive patients who have no function, or who have impaired function, of a respiratory center, for example, sedated patients, intensive care patients or anesthetized patients. Regular repetitive induction can be, in particular, from ten to fifty stimuli per minute. The lack of function of the respiratory center can result from drugs or opioid consumption. Use may be involved in immediate therapy for patients without stimuli due to the interrupted connection between the respiratory center and the diaphragm such as, for example, paraplegic patients after accidents, for use in patients without stimuli due to sedation or depression respiratory, or for use in mechanically ventilated patients without stimulation.
[037] [037] The electromagnetic induction device according to the invention and its preferred modalities can also be advantageously used for repetitive transcutaneous electromagnetic induction of a phrenic nerve for therapeutic use in patients without spontaneous contractions of the diaphragm, or with spontaneous contractions of the diaphragm insufficiently, that have at least one phrenic nerve partially intact. Such therapeutic applications may include, for example, treating or preventing weakness of the diaphragm in mechanically ventilated patients, preventing or treating lung infections in mechanically ventilated patients, preventing or treating lung injuries or other positive pressure-related complications, for use in patients with COPD, for resuscitation and keeping patients alive who have impaired function of the respiratory center (for example, drugs or opioids), for treatment of sleep apnea and other forms of breathing due to sleep disorders; to treat patients with idiopathic diaphragmatic paralysis, neural amyotrophy or ALS, treat hypercapnia. For these applications, it can be useful to design the coil positioning mechanism as follows: The patient is lying on a pillow or mattress that adapts its shape to the patient's anatomy. It could be a vacuum pillow, where the patient's head could be fixed in a position after vaccumization. The coils are fixed on a retainer, which is mounted to the mattress or bed or which is placed on the mattress below the vacuum pillow. An automated adjustment mechanism is included in the coil retainer, to change the direction of the stimulus. The coil adjustment and construction mechanism can be surrounded by a cleanable or disposable cover, to protect the patient against mechanical movements of the coil and to protect the coil mechanism against decontamination.
[038] [038] Preferably, the calibration unit is configured (i) to control the electromagnetic field generator to generate the electromagnetic field in pulses while the position of the electromagnetic field generated by the coil design is varied, and (ii) to control the electromagnetic field generator to generate the electromagnetic field like a train when the variation in the position of the electromagnetic field generated by the coil design is stopped. By separating between the provision of pulses by adjusting the position of the electromagnetic field and a train that stimulates the target tissue, optimized activation of the target tissue can be achieved depending on its purpose. In particular, having an appropriate position of the electromagnetic field, the target tissue or a nerve associated with it needs to be located.
[039] [039] Thus, the calibration unit is preferably configured to control the electromagnetic field generator to generate the electromagnetic field as a train with an initially lower field strength and then increasing in relation to the locally targeted electromagnetic field. constricted in pulses. In particular, the train's field strength may initially be slightly less to avoid discomfort, then gradually increase until a desired muscle contraction intensity is achieved and, ultimately, the train's field strength may be greater than the intensity of the pulses. Similarly, one can ensure that the target tissue is safely stimulated after the correct electromagnetic field position is found.
[040] [040] Preferably, the activation feedback signal comprises several activation responses from the target tissue each associated with a specific position and, eventually, a specific field strength of the electromagnetic field generated by the coil design, and the calibration unit is configured to control the electromagnetic field adjustment mechanism to adjust the position and eventually the field strength of the electromagnetic field to the specific position associated with the most appropriate response among the various responses of the activation feedback signal or the most desirable signal characteristic, when the activation feedback signal is received. The term “most appropriate” according to the usage in question can refer particularly to an intensity of the response. In particular, the most appropriate response may be the strongest response. In addition or alternatively, the most appropriate response can also be determined by other response properties. Similarly, the best position and the most efficient position and, eventually, the field strength of the electromagnetic field can be determined and adjusted. In particular, by accumulating several responses for various positions and eventually field strengths and selecting the strongest or most appropriate response first, the configuration of the electromagnetic field can be optimized. The term "strong" in connection with the response can refer to a resistance or activity intensity of the target tissue. This resistance or intensity can correlate to the resistance or intensity of the signal provided by the sensor member.
[041] [041] Preferably, the activation feedback signal comprises several target tissue activation responses each associated with a specific position in the target area of the electromagnetic field generated by the coil design, and the calibration unit is configured to control the mechanism of electromagnetic field adjustment to adjust the position of the electromagnetic field to the specific position associated with the most appropriate response characteristic of the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the field characteristics time to specific position and time adjustments associated with the most appropriate response among the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the temporal field characteristics to the specific position and timing adjustments associated with the most appropriate response characteristic of the responses of the activation feedback signal, when the activation feedback signal is received.
[042] [042] In another aspect, the invention consists of a process for the manufacture of an electromagnetic induction device to activate a target tissue in a human or animal body through its muscular or neural system. The process comprises: (i) assembling (ia) an electromagnetic field generator with a coil design configured to generate a spatial electromagnetic field having a desired shape, (ib) a mounting arrangement maintaining the coil design of the electromagnetic field generator in the body of a human or animal, and (ic) a sensor member configured to detect an activation of the target tissue, to the electromagnetic induction device, (ii) assemble (ii.a) an electromagnetic field adjustment mechanism configured to automatically adjust the position of the electromagnetic field generated by the coil design, and (ii.b) a calibration unit in communication with the sensor member and the electromagnetic field adjustment mechanism, to the electromagnetic induction device, and configure the calibration unit (iii.a) for controlling the electromagnetic field adjustment mechanism to automatically vary the position of the electromagnetic field generated by the coil design, (ii ib) to receive an activation feedback signal from the sensor member upon detection of target tissue activation, and (iii.c) control the electromagnetic field adjustment mechanism to automatically stop the variation of the position of the generated electromagnetic field by the coil design when activation feedback is received.
[043] [043] The process according to the invention allows to manufacture efficiently the manufacture of the electromagnetic induction device according to the invention, as well as its preferred modalities. In this way, the effects and benefits described above can be obtained in connection with the electromagnetic induction device according to the invention.
[044] [044] Preferably, the mounting arrangement is provided with a repositioning structure configured to automatically change a position of the coil design of the electromagnetic field generator in relation to the body of a human or animal when it is kept in the body of a human being or an animal. In this way, the electromagnetic field adjustment mechanism is preferably provided with a structure for repositioning the mounting arrangement and the calibration unit is preferably configured to automatically vary the position of the electromagnetic field by inducing the structure of repositioning to automatically change the position of at least two electromagnetic coils in relation to the body of a human or animal.
[045] [045] Preferably, the electromagnetic field generator has a repositionable conductive element located in the electromagnetic field generated by the coil design. In this way, the electromagnetic field adjustment mechanism is preferably provided with a conducting element of the electromagnetic field generator and the calibration unit is preferably configured to automatically vary the position of the electromagnetic field by inducing the adjustment of electromagnetic field to automatically reposition the conductive element in the electromagnetic field. Preferably, the conducting element is provided with a conducting axis.
[046] [046] Preferably, the electromagnetic field generator is equipped with a coil arrangement including the coil design. In this way, the electromagnetic field adjustment mechanism is preferably provided with a coil arrangement of the electromagnetic field generator and the calibration unit is preferably configured to automatically vary a position of the electromagnetic field by inducing the mechanism of electromagnetic field adjustment to automatically enable different coil combinations of the coil arrangement. Preferably, the coils in the coil arrangement overlap. Preferably, the coil arrangement of the electromagnetic field generator is arranged to generate a plurality of spatial electromagnetic fields having a desired shape, with the coil arrangement being arranged so that the plurality of electromagnetic fields overlap and generate an accumulated intensity .
[047] [047] Preferably, the sensor member is provided with at least one electrode configured to be attached to the body of a human or animal so that it captures an activity of the target tissue.
[048] [048] Preferably, the sensor member is provided with a flow sensor having an adapter connectable to a respiratory system in the body of a human or animal, the flow sensor being configured to detect a change in flow of air induced by a target tissue activity. In this way, the flow sensor adapter of the sensor member is preferably configured to be connected to a mouth and / or a nose on the body of a human or animal.
[049] [049] Preferably, the mounting arrangement is configured to maintain the coil design on the neck of the body of a human or animal so that a phrenic nerve in the neural system of the body of a human or animal can be reached by the electromagnetic field generated by the coil design of the electromagnetic field generator. In this way, the mounting arrangement is preferably provided with an arc member capable of being arranged at a distance around the neck of the body of a human or animal, the two coils of the electromagnetic field generator being kept in the arc member of the mounting arrangement. Preferably, the arch member is equipped with an access passage.
[050] [050] Preferably, the process further comprises a step of mounting a tracker on the electromagnetic induction device, in which the tracker is configured to detect a movement of the body of a human or animal in relation to the coil design of the electromagnetic field generator and to automatically change the position of the electromagnetic field to compensate for the detected movement of the body of a human or animal in relation to the coil design of the electromagnetic field generator.
[051] [051] Preferably, the electromagnetic field adjustment mechanism is configured to automatically adjust an electromagnetic field strength generated by the coil design and the calibration unit is configured to control the electromagnetic field adjustment mechanism to automatically vary the field strength of the electromagnetic field generated by the coil design and control the electromagnetic field adjustment mechanism to automatically stop the variation in the field strength of the electromagnetic field generated by the coil design when activation feedback is received.
[052] [052] Thus, the process preferably comprises: mounting an alarm unit on the electromagnetic induction device, in which the tracker is connected to the alarm unit and configured to activate the alarm unit when the detected movement exceeds a range of compensation attainable by changing the position of the electromagnetic field generated by the two coils through the electromagnetic field adjustment mechanism. The alarm can be an acoustic, visual or tactile signal, or any combination thereof.
[053] [053] Preferably, the process comprises a step of configuring the calibration unit (i) to control the electromagnetic field generator to generate the electromagnetic field in pulses as long as the position of the electromagnetic field generated by the coil design is varied, and ( ii) to control the electromagnetic field generator to generate the electromagnetic field like a train when the variation in the position of the electromagnetic field generated by the coil design is interrupted.
[054] [054] Thus, the process preferably comprises a step of configuring the calibration unit to control the electromagnetic field generator to generate the electromagnetic field like a train with an initially lower field strength and increasing field strength in relation to the electromagnetic field in pulses.
[055] [055] Preferably, the activation feedback signal comprises several activation responses from the target tissue associated with a specific position of the electromagnetic field generated by the coil design, and the calibration unit is configured to control the electromagnetic field adjustment mechanism to adjust the position of the electromagnetic field to the specific position associated with the strongest or most appropriate response among the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting temporal field characteristics to the specific position and time adjustments associated with a more appropriate response among the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the temporal field characteristics to the specific position and timing adjustments associated with the activation characteristic. most appropriate response among the various responses activation feedback signal, when the activation feedback signal is received.
[056] [056] Preferably, the activation feedback signal comprises several target tissue activation responses each associated with a specific position in the target area of the electromagnetic field generated by the coil design, which comprises configuring the calibration unit to control the mechanism of electromagnetic field adjustment to adjust the position of the electromagnetic field to the specific position associated with the appropriate response characteristic of the various responses of the activation feedback signal, when the activation feedback signal is received.
[057] [057] Preferably, the process comprises configuring the electromagnetic field adjustment mechanism to automatically adjust the temporal characteristics of the electromagnetic field and configuring the calibration unit to control the electromagnetic field adjustment mechanism to automatically vary the temporal characteristics of the electromagnetic field and, optionally, control the electromagnetic field adjustment mechanism to automatically stop the variation of the temporal characteristics of the electromagnetic field generated by the coil design when activation feedback is received.
[058] [058] In another additional aspect, the invention consists of a method to activate a target tissue in a human or animal body through its muscular or neural system, which comprises: (i) positioning the coil design in the body of a human or animal, (ii) generate a spatial electromagnetic field having a desired shape through the coil design, (iii) capture for activation of the target tissue, (iv) adjust a position of the electromagnetic field generated by the coil design, (v) automatically vary the position of the electromagnetic field generated by the coil design, (vi) evaluate the activation feedback obtained by capturing to activate the target tissue, and (vii) automatically stop the variation of the position of the electromagnetic field generated by the coil project when an activation is detected by the capture to activate the target tissue.
[059] [059] This method allows efficient activation of the target tissue. This can be beneficial, for example, to avoid any defects resulting from the disuse of the target tissue. In particular, when used in a ventilation application, this method can prevent the diaphragm from malfunctioning as a result of not being used during ventilation. More specifically, the method according to the invention allows to achieve the effects and benefits described above in connection with the electromagnetic induction device according to the invention.
[060] [060] Thus, automatically varying the position of the electromagnetic field preferably comprises automatically changing the position of at least two electromagnetic coils in relation to the body of a human or animal. Automatically varying the position of the electromagnetic field preferably comprises automatically repositioning a conductive element in the electromagnetic field.
[061] [061] Preferably, the electromagnetic field generator comprises a coil arrangement including the coil design. In this way, automatically varying the position of the electromagnetic field comprises automatically enabling different coil combinations in the coil arrangement. Preferably, the coils in the coil arrangement overlap. Preferably, the coil arrangement of the electromagnetic field generator is arranged to generate a plurality of electromagnetic fields each having a locally constrained targeted electric field, with the coil arrangement being arranged so that the plurality of electromagnetic fields overlap and generate an accumulated intensity.
[062] [062] Preferably, the capture for activation of the target tissue comprises attaching at least one electrode to the body of a human or animal.
[063] [063] Preferably, the capture for activation of the target tissue comprises connecting a flow sensor to a respiratory system in the body of a human or animal, and detecting a change in airflow induced by an activity of the target tissue. In this way, the flow sensor is preferably connected to a mouth and / or a nose on the body of a human or animal.
[064] [064] Preferably, the positioning of the coil design on the body of a human or animal comprises maintaining the coil design on a neck of the body of a human or animal so that a phrenic nerve of the neural system of a human or animal body can be reached by the electromagnetic field generated by the coil design. Advantageously, both sides of the neck are involved in activating the diaphragm. In particular, two electromagnetic induction devices can be placed parallel to the neck so that phrenic nerves can be stimulated on both sides.
[065] [065] Preferably, the method comprises automatically adjusting the field strength of the electromagnetic field generated by the coil design, automatically varying the field strength of the electromagnetic field generated by the coil design and stopping the variation in the field strength of the generated electromagnetic field by the coil design when an activation of the target tissue is captured.
[066] [066] Preferably, the method comprises generating the electromagnetic field in pulses while the position of the electromagnetic field generated by the coil design is varied, and generating the electromagnetic field like a train when the position variation of the target area of the electromagnetic field generated by the coil design is stopped.
[067] [067] Thus, the method preferably comprises generating the electromagnetic field as a train with an initially lower field strength and then an increasing field strength in relation to the pulsed electromagnetic field.
[068] [068] Preferably, the activation feedback signal comprises several activation responses from the target tissue each associated with a specific position of the electromagnetic field generated by the coil design, and the position of the electromagnetic field is adjusted to the specific position associated with the response stronger or more appropriate among the various responses of the activation feedback signal, when the activation feedback signal is received.
[069] [069] The electromagnetic field generator of all modalities described in this document is advantageously configured to provide pulses of electromagnetic fields, with adjustable field strength and frequency. Similarly, a sudden seizure of the patient or specific body parts can be prevented. This can increase the convenience and efficiency of the stimulus.
[070] [070] Preferably, the activation feedback signal comprises several activation responses from the target tissue each associated with a specific position in the target area of the electromagnetic field generated by the coil design, and the position of the electromagnetic field is adjusted to the specific position associated with the most appropriate response characteristic of the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the temporal field characteristics to the specific position and timing adjustments associated with the most appropriate response among the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the temporal field characteristics to the specific position and timing adjustments associated with the most appropriate characteristic response among the various responses of the feedback feedback signal. activation, when the activation feedback signal is not received.
[071] [071] Preferably, the method comprises adjusting the temporal characteristics of the electromagnetic field and varying the temporal characteristics of the electromagnetic field and, optionally, stopping the variation of the temporal characteristics of the electromagnetic field generated by the coil design when the activation feedback is received. BRIEF DESCRIPTION OF THE DRAWINGS
[072] [072] The electromagnetic induction device according to the invention, as well as the process and method according to the invention will be described in greater detail below by way of exemplary modalities and with reference to the attached drawings, in which:
[073] [073] Figure 1 shows a first implementation of a ventilation machine having a first modality of an electromagnetic induction device according to the invention;
[074] [074] Figure 2 shows an electromagnetic field generator for the electromagnetic induction device of Figure 1;
[075] [075] Figure 3 shows a spatial electromagnetic field generated by the electromagnetic induction device of Figure 1;
[076] [076] Figure 4 shows a second implementation of a ventilation machine having a second embodiment of an electromagnetic induction device according to the invention;
[077] [077] Figure 5 shows an electromagnetic field generator of a third modality of an electromagnetic induction device according to the invention in an inclined state;
[078] [078] Figure 6 shows the electromagnetic field generator of Figure 5 in a non-tilted state;
[079] [079] Figure 7 shows a third implementation of a ventilation machine having a fourth modality of an electromagnetic induction device according to the invention.
[080] [080] Figure 8 shows a fifth embodiment of an electromagnetic induction device according to the invention;
[081] [081] Figure 9 shows a spatial electromagnetic field generated by a sixth modality of an electromagnetic induction device according to the invention;
[082] [082] Figure 10 shows a flow diagram of a first modality of a method for activating a target tissue in a human or animal body through its muscular or neural system according to the invention;
[083] [083] Figure 11 shows a flow diagram of a second modality of a method for activating a target tissue in a human or animal body through its muscular or neural system according to the invention; and
[084] [084] Figure 12 shows a flow diagram of a third modality of a method for activating a target tissue in a human or animal body through its muscular or neural system according to the invention. DESCRIPTION OF THE MODALITIES
[085] [085] In the description that follows, certain terms are used for convenience and are not intended to limit the invention. The terms "right", "left", "up", "down", "under" and "over" refer to directions in the figures.
[086] [086] To avoid repetition in the figures and descriptions of the various aspects and illustrative modalities, it must be understood that many resources are common to many aspects and modalities. The omission of an aspect of a description or figure does not imply that the aspect is absent from the modalities that incorporate that aspect.
[087] [087] Figure 1 shows a first implementation of a ventilation machine 1 having a first embodiment of an electromagnetic induction device 2 (hereinafter also referred to as an EMI device) according to the invention. The EMI device 2 comprises an electromagnetic field generator 21 with two coils 211 as a coil design. Coils 211 are located on a common plane and configured to generate a spatial electromagnetic field 212. As can be seen particularly in
[088] [088] Turning to Figure 1, the EMI device 2 has a mounting arrangement 22 with a neck arch 221 arranged on the neck 52 of patient 5 and attached to a bed 51 on which patient 5 is lying. A neck arc 221 is equipped with a joint 222 as a repositioning structure for an electromagnetic field adjustment mechanism of the EMI device 2. Joint 222 holds the coils 211 on the patient's neck 52.
[089] [089] The ventilation machine 1 further comprises a fan 11 as an air flow generator from which ventilation tubes 13 extend. The EMI device 2 has a mouthpiece 12 as an adapter, that is, as a duct interface of the ventilation machine 1. The mouthpiece 12 is applied to a mouth as an entry point into the patient's respiratory system 5. The ventilation tubes 13 are coupled to a flow sensor 41 of a sensor member 4 of the EMI device
[090] [090] The EMI device 2 also has a controller 3 as a processing unit with a calibration unit 31 and a field adjustment unit 32 of the electromagnetic field adjustment mechanism. Controller 3 is in communication with flow sensor 41 and gasket 222 through respective wires 33.
[091] [091] The calibration unit 31 is configured to manipulate joint 222 to automatically vary the position of the focus area 213 of the electromagnetic field 212 generated by coils 211 and controller 3 to vary the field strength of the electromagnetic field 212. The objective the variable field strength and the position of the electromagnetic field 212 consists of adjusting the electromagnetic field 212 so that it specifically stimulates a phrenic nerve 53 of the patient 5 as best seen in Figure 3. By stimulating the phrenic nerve 53, a diaphragm of the patient 5 is activated. In this way, a flow of air or breath is induced that is captured by the flow sensor 41.
[092] [092] The calibration unit 31 is configured to receive an activation feedback signal from the flow sensor 41 upon detection of diaphragm activation or upon detection of airflow. In addition, it is configured to stop the variation of the position of the focus area 213 of the electromagnetic field 212 and of the controller 3 to stop the variation of the field strength of the electromagnetic field 212 when the activation feedback is received.
[093] [093] Ventilator 11 is configured to deliver air through nozzle 12 in the patient's respiratory system 5. In this way, controller 3 is configured to control ventilator 11 to deliver air to the respiratory system according to a breathing scheme defined in controller 3. In particular, controller 3 regulates the activation of the diaphragm in coordination with the breathing scheme so that the activation of the diaphragm through the phrenic nerve 53 is coordinated with the patient's ventilation 5.
[094] [094] In Figure 2, the coils 211 of the electromagnetic field generator 21 are shown in greater detail. In this way, it can be seen that the coils 211 are connected to the neck arch 221 through the joint 222. As indicated by the arrows in Figure 2, the joint 222 can be tilted through the control unit 31 so that also the coils 211 are commonly tilted or rotated.
[095] [095] The EMI device 2 is additionally equipped with a tracker 23 which is configured to detect movement of the patient 5 in relation to the coils 211 and automatically induce a change in the position of the electromagnetic field 212 to compensate for the detected movement of the patient 5. Tracker 23 is in communication with an alarm unit. It activates the alarm unit when the detected movement exceeds an attainable compensation range by changing the position of the 212 electromagnetic field.
[096] [096] Controller 3 is equipped with a wireless adapter to be connected to a mobile device such as a smartphone, a tablet, or the like, as an input interface. When the mobile device is connected, an operator can enter an appropriate cyclic breathing scheme suitable for treating the patient
[097] [097] Figure 4 shows a second implementation of a ventilation machine 10 having a second embodiment of an EMI device 20 according to the invention. The EMI device 20 comprises an electromagnetic field generator 210 with two coils 2110. Coils 2110 are configured to generate a spatial electromagnetic field with a desired shape. The EMI device 20 also has a mounting arrangement 220 with a tape 2210. The tape 2210 is provided with an adhesive and attached to a neck 520 of a patient 50.
[098] [098] The EMI 20 device is equipped with a 2220 axis as a repositionable element that extends towards the coils 2110 and can tilt the electromagnetic field around a geometric axis of the axis.
[099] [099] The ventilation machine 10 comprises a fan 110 as an air flow generator from which the ventilation tubes 130 extend. The EMI device 20 has a mouthpiece 120 as an adapter or as a duct interface of the ventilation machine 10. The mouthpiece 120 is applied to a mouth as an entry point into the patient's respiratory system 50.
[0100] [0100] The EMI device 20 has a controller 30 as a processing unit with a calibration unit 310 and a field adjustment unit 320 of the electromagnetic field adjustment mechanism. In the patient's body 50, a plurality of electrodes 410 is composed of a sensor member 40 to detect activation of the diaphragm. Controller 30 is in communication with electrodes 410 and magnetic stimulator 325 which connects to axis 2220 through the respective wires 330.
[0101] [0101] The calibration unit 310 is configured to automatically vary the position of the electromagnetic field by automatically inducing the field adjustment unit 320 to reposition axis 2220 and automatically varying the intensity of the electromagnetic field. In particular, axis 2220 influences the alignment of the electromagnetic field around the geometric axis of the axis and thus the location of the target area. Then, by moving the 2220 axis, the electromagnetic field can be relocated. In this way, the electromagnetic field can be moved within the neck 520 of patient 50. In particular, the calibration unit 310 is configured to vary the position of the electromagnetic field and vary the field strength of the electromagnetic field. In this way, the electromagnetic field can be adjusted so that it specifically stimulates a patient's phrenic nerve 50. By stimulating the phrenic nerve, a diaphragm of the patient 50 is activated, which is captured by electrodes 410.
[0102] [0102] The calibration unit 310 is configured to receive an activation feedback signal from electrodes 410 upon detection of activation of the diaphragm. Furthermore, it is configured to stop the variation of the position of the electromagnetic field and to control the controller 30 to stop the variation of the field strength of the electromagnetic field when the activation feedback is received. Ventilator 110 is configured to deliver air through nozzle 120 to patient's respiratory system 50. Controller 30 is configured to control ventilator 110 so that its delivery of air to the respiratory system is aligned with a breathing scheme defined in controller 30 In particular, controller 30 regulates the activation of the diaphragm in coordination with the breathing scheme so that the activation of the diaphragm through the phrenic nerve is coordinated with the patient's ventilation and breathing 50.
[0103] [0103] Controller 30 is equipped with a wireless adapter to be connected to a mobile device such as a smartphone, a tablet, or the like, such as the input interface. When the mobile device is connected, an operator can enter an appropriate cyclic breathing scheme suitable to treat the patient 50. The breathing scheme is incorporated so that the controller 30 induces ventilation and phrenic nerve stimulation in a predefined and patient-specific manner patient. In this way, the ventilator 110 delivers air through the nozzle 120 in the patient's respiratory system 50 by applying cycles of sending air into the patient's respiratory system 50 and drawing air out of the respiratory system according to the breathing scheme. In addition, the EMI 20 device activates the diaphragm just before each start of one of the cycles of the breathing scheme.
[0104] [0104] In Figure 5, an electromagnetic field generator 219 of a third embodiment of an EMI device according to the invention is shown.
[0105] [0105] In Figure 5, coils 2119 are described in an inclined state in which the left coil 2119 is higher than the right coil 2119. To change the inclination of coils 2119, one of the pipes 2139 can be pulled. As can be seen in Figure 6, to move the coils 2119 back to a straight position, the left cable 2139 is pulled so that the coils 2119 are rotated counterclockwise.
[0106] [0106] Figure 7 shows a third implementation of a ventilation machine 18 having a fourth embodiment of an EMI device 28 according to the invention. The EMI device 28 comprises an electromagnetic field generator 218 with two coils 2118 as a coil design. The electromagnetic field generator 218 has a housing 2128 in which an axis 2228 of a mounting arrangement 228 extends. Axis 2228 is coupled to a transmission shaft 2238 through which axis 2238 can be moved in the electromagnetic field once created by coils 2118.
[0107] [0107] The ventilation machine 18 comprises a fan from which ventilation tubes are connected to a nozzle 128 as an adapter or as a duct interface of the ventilation machine 18 via a flow sensor 418 of a sensor member 48. Nozzle 128 is applied to a patient's mouth 58 as an entry point into their respiratory system.
[0108] [0108] The EMI device 28 has a controller 38 as a processing unit with a calibration unit and a field adjustment unit.
[0109] [0109] The ventilation apparatus 18 is operated correspondingly as the ventilation apparatus 10 described above in connection with Figure 4.
[0110] [0110] In Figure 8, the components of a fifth embodiment of an EMI device 27 according to the invention are shown. The EMI device 27 is similarly incorporated as the EMI devices described above in connection with the previous figures. However, a mounting arrangement 227 comprises an arc member 2217 to which the coils 2117 of an electromagnetic field generator 217 are mounted as a coil design. Bow member 2217 is positioned around a neck 527 of a patient 57. Coils 2117 can be moved along bow member 2217 and thereby around neck 527 of patient 57. Additionally, coils 2117 they can bypass the arc member 2217. Through these movements of the coils 2117, a spatial electromagnetic field and, in particular, a desired shape of the same can be moved around and around the neck 527 to find and stimulate a patient's phrenic nerve 57.
[0111] [0111] Figure 9 shows electromagnetic fields generated by coils of a sixth modality electromagnetic field generator of an EMI device according to the invention. In particular, the electromagnetic field generator comprises two pairs of coils where the pairs are perpendicular to each other. Therefore, a first pair of coils generates a first electromagnetic field 2126 having a desired shape with a first focus area 2136. The second pair of coils generates a second electromagnetic field 2146 having a desired shape with a second focus area 2156. Since the coils of the first air are perpendicular to the coils of the second pair, the first electromagnetic field and the second electromagnetic field overlap in their respective areas of focus 2136, 2156. Similarly, an area of accumulated intensity 2166 is created where the areas of focus 2136, 2156 overlap. A phrenic nerve 536 is positioned in the area of accumulated intensity 2166.
[0112] [0112] Figure 10 shows a first embodiment of a method for activating a target tissue in a human or animal body through its muscular or neural system according to the invention. The first method can, for example, be performed using the electromagnetic induction device 2 shown in Figure 1.
[0113] [0113] In a first step 101, the coils are positioned in the body of a human or animal close to a target nerve. For example, coils can be positioned around a neck so that they are close to a phrenic nerve. In a second step 102, a spatial electromagnetic field having a desired shape is generated through the coils. In a third stage 103, it is captured if the target tissue associated with the target nerve is activated. If this is the case, in a fourth step 104, the position of the coils and the intensity of the electromagnetic field are frozen or maintained and the target nerve is repeatedly stimulated.
[0114] [0114] If in the third step 103, no activation of the target tissue is captured, in a series of sub-steps, the position of the electromagnetic field and the field strength of the electromagnetic field are automatically varied as follows: In a first sub- step 103i, the position of the coils is adjusted by tilting the coils to a predefined length. Then, in a second sub-step 103ii, it is picked up again if the target tissue is activated. If this is the case, the fourth step 104 is carried out as described above. If no activation is detected again, the field strength of the electromagnetic field is adjusted in a third sub-step 103iii. After that, in a fourth sub-step 103iv, it is captured again if the target tissue is activated. If this is the case, the method is proceeded with the fourth step 104 as previously described. If no activation is received again, the sequence of sub-steps is repeated.
[0115] [0115] In Figure 11, a second embodiment of a method for activating a target tissue in a human or animal body through its muscular or neural system according to the invention is shown. The second method is similar to the first method described earlier in which a tracking of movements and components involved, and particularly of the body, is included.
[0116] [0116] In particular, in a first step 201, the coils are positioned in the body of a human or animal close to a target nerve.
[0117] [0117] If in the fourth step 204, no activation of the target tissue is captured, in a series of sub-steps, the position of the electromagnetic field and the field strength of the electromagnetic field are automatically varied as follows: In a first sub- step 204i, the position of the coils is adjusted by tilting the coils to a predefined length. Then, in a second sub-step 204ii, it is captured again if the target tissue is activated. If this is the case, the fifth step 205 is carried out as described previously. If no activation is detected again, the field strength of the electromagnetic field is adjusted in a third sub-step 204iii. After that, in a fourth sub-step 204iv, it is captured again if the target tissue is activated. If this is the case, the method is proceeded with the fifth step 205 as described previously. If no activation is received again, the sequence of sub-steps is repeated.
[0118] [0118] After stopping the automatic variation of the coils and freezing the electromagnetic field in step 205, the relocation of the tracker that indicates a movement of the body is monitored in a sixth step 206. If no relocation is detected, the method continues in step 205. If, however, a relocation is detected, in an eighth step 208, an alarm is provided.
[0119] [0119] Figure 12 shows a third modality of a method for activating a target tissue in a human or animal body through its muscular or neural system according to the invention. The third method is similar to the second method described earlier in which the automatic readjustment of the electromagnetic field is involved when a relocation of the body in relation to the coils is detected.
[0120] [0120] In particular, in a first step 301, the coils are initially positioned in the body of a human or animal close to a target nerve.
[0121] [0121] If in the fourth step 304 no activation of the target tissue is captured, in a series of sub-steps, the position of the electromagnetic field and the field strength of the electromagnetic field are automatically varied as follows: in a first sub-step 304i, the position of the coils is adjusted by tilting the coils to a predefined length. Then, in a second sub-step 304ii, it is captured again if the target tissue is activated. If this is the case, the fifth step 305 is performed as described above. If no activation is detected again, the field strength of the electromagnetic field is adjusted in a third sub-step 304iii. After that, in a fourth sub-step 304iv, it is captured again if the target tissue is activated. If this is the case, the method is proceeded with the fifth step 305 as described previously. If no activation is received again, the sequence of sub-steps is repeated.
[0122] [0122] After stopping the automatic variation of the coils and freezing the electromagnetic field in step 305, the relocation of the tracker that indicates a movement of the body is monitored in a sixth step 306. If no relocation is detected, the method is continued in step 305 If, however, a relocation is detected, in an eighth step 308, the position of the coils and the field strength of the electromagnetic field are reset to the same starting position and field strength as in steps 301 and 303. Then, in a ninth step 309, the coils are reclined and the electromagnetic field readjusted to an expected position and field strength according to the detected relocation. In this way, the degree and direction of relocation are considered. After that, the method is continued in sub-step 304ii of the sequence of sub-steps.
[0123] [0123] The present description and the accompanying drawings that illustrate aspects and modalities of the present invention should not be taken as limiting the claims that define the protected invention. In other words, although the invention has been illustrated and described in detail in the drawings and in the previous description, this illustration and description must be considered illustrative or exemplary and without restrictive character. Various mechanical, compositional, structural, electrical and operational changes can be made without departing from the scope and scope of this description and the claims. In some cases, circuits,
[0124] [0124] The disclosure also covers all additional features shown in the figures individually although they may not have been described in the previous or next description. Likewise, unique alternatives of the exclusive modalities in the figures and description and exclusive alternatives of resources of the same can be rejected from the material of the invention or from the material revealed. The disclosure comprises a subject that consists of resources defined in the claims or in the exemplifying modalities, as well as the subject that comprises said resources.
[0125] [0125] Additionally, in the claims, the term “which comprises” does not exclude other elements or stages, and the indefinite articles “one” or “one” do not exclude a plurality. A single unit or step can fulfill the functions of several resources mentioned in the claims. The mere fact that certain measures are cited in the mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage. The terms "essentially", "about", "approximately" and the like in connection with an attribute or a value particularly also define exactly the attribute or exactly the value, respectively. The term “about” in the context of a given value or numerical range refers to a value or range that is, for example, within 20%, within 10%, within 5%, or within 2% of the data value or range. The components described as coupled or connected can be electrically or mechanically coupled directly, or they can be indirectly coupled through one or more intermediate components.
Any reference signs in the claims should not be construed as limiting the scope.

权利要求:
Claims (69)
[1]
1. Electromagnetic induction device (2; 20; 27; 28) to activate a target tissue in a human or animal body through its muscular or neural system, which comprises an electromagnetic field generator (21; 210 ; 217; 218; 219) with a coil design (211; 2110; 2117; 2118; 2119) configured to generate a spatial electromagnetic field (212; 2126, 2146) having a desired shape (213; 2136, 2156), a mounting arrangement (22; 220; 227; 228) that maintains the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) on the body of a being human or animal, and a sensor member (4; 40; 48) configured to detect an activation of the target tissue, CHARACTERIZED by the fact that it comprises an electromagnetic field adjustment mechanism (21; 210; 217; 218; 219 ) configured to automatically adjust the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119), and a calibration unit (31; 310; 38) in communication with the sensor member (4; 40; 48) and with the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219), in which the calibration unit (31; 310; 38) is configured to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically vary the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118 ; 2119), receive an activation feedback signal from the sensor member (4; 40; 48) upon detection of target tissue activation, and control the electromagnetic field adjustment mechanism (21; 210; 217; 218 ; 219) to automatically stop the variation of the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when the activation feedback signal is received.
[2]
2. Electromagnetic induction device (2; 20; 27; 28), according to claim 1, CHARACTERIZED by the fact that the mounting arrangement (22; 220; 227; 228) comprises the repositioning structure (222; 2129 , 2139) configured to automatically change a position of the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) in relation to the body of a human or an animal while being held in the body of a human or animal.
[3]
3. Electromagnetic induction device (2; 20; 27; 28), according to claim 2, CHARACTERIZED by the fact that the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) comprises the structure of repositioning (222; 2129, 2139) of the mounting arrangement (22; 220; 227; 228) and the calibration unit (31; 310; 38) is configured to automatically vary the position of the electromagnetic field (212; 2126, 2146) inducing the repositioning structure (222; 2129, 2139) to automatically change the position of the coil design (211; 2110; 2117; 2118; 2119) in relation to the body of a human or animal.
[4]
4. Electromagnetic induction device (2; 20; 27; 28), according to claim 2 or 3, CHARACTERIZED by the fact that the repositioning structure (222; 2129, 2139) of the mounting arrangement (22; 220; 227; 228) comprises a tilt mechanism such as a joint (222) configured to tilt the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) in relation to the body of a human or animal when being kept in the body of a human or animal.
[5]
5. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that the electromagnetic field generator (21; 210; 217; 218; 219) comprises a conductive element repositionable located in the electromagnetic field (212; 2126, 2146) generated by the coil project (211; 2110; 2117; 2118; 2119).
[6]
6. Electromagnetic induction device (2; 20; 27; 28), according to claim 5, CHARACTERIZED by the fact that the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) comprises the conductive element of the electromagnetic field generator (21; 210; 217; 218; 219) and the calibration unit (31; 310; 38) is configured to automatically vary the position of the electromagnetic field (212; 2126, 2146) by inducing the mechanism of electromagnetic field adjustment (21; 210; 217; 218; 219) to automatically reposition the conductive element in the electromagnetic field (212; 2126, 2146).
[7]
7. Electromagnetic induction device (2; 20; 27; 28), according to claim 5 or 6, CHARACTERIZED by the fact that the conductive element (2220; 2228) comprises a conductive axis.
[8]
8. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that the electromagnetic field generator (21; 210; 217; 218; 219) comprises an array of coils (211; 2110; 2117; 2118; 2119) including the coil design (211; 2110; 2117; 2118; 2119).
[9]
9. Electromagnetic induction device (2; 20; 27; 28), according to claim 8, CHARACTERIZED by the fact that the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) comprises the arrangement of coils (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) and the calibration unit (31; 310; 38) is configured to automatically vary the position of the electromagnetic field (212; 2126, 2146) by inducing the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically enable different coil combinations in the coil arrangement (211; 2110;
2117; 2118; 2119).
[10]
10. Electromagnetic induction device (2; 20; 27; 28), according to claim 8 or 9, CHARACTERIZED by the fact that the coils (211; 2110; 2117; 2118; 2119) of the coil arrangement (211; 2110; 2117; 2118; 2119) overlap.
[11]
11. Electromagnetic induction device (2; 20; 27; 28) according to any one of claims 8 to 10, CHARACTERIZED by the fact that the coil arrangement (211; 2110; 2117; 2118; 2119) of the generator electromagnetic field (21; 210; 217; 218; 219) is arranged to generate a plurality of electromagnetic fields each having a desired shape (213; 2136, 2156), with the coil arrangement (211; 2110; 2117; 2118 ; 2119) is arranged so that the plurality of electromagnetic fields overlap and generate an accumulated intensity (2166).
[12]
12. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that the sensor member (4; 40; 48) comprises at least one electrode configured to be fixed to the body of a human or animal so that it captures an activity from the target tissue.
[13]
13. Electromagnetic induction device (2; 20; 27; 28) according to any one of the preceding claims, CHARACTERIZED by the fact that the sensor member (4; 40; 48) comprises a flow sensor (41; 418 ) having an adapter (12; 120) connectable to a respiratory system in the body of a human or animal, the flow sensor (41; 418) being configured to detect an airflow change induced by an activity of the target tissue.
[14]
14. Electromagnetic induction device (2; 20; 27; 28) according to claim 13, CHARACTERIZED by the fact that the adapter (12; 120) of the flow sensor (41; 418) of the sensor member (4 ; 40; 48) is configured to be connected to a mouth and / or nose on the body of a human or animal.
[15]
15. Electromagnetic induction device (2; 20; 27; 28), according to any of the preceding claims, CHARACTERIZED by the fact that the mounting arrangement (22; 220; 227; 228) is configured to maintain the design of coil (211; 2110; 2117; 2118; 2119) in the neck (52; 520; 527; 528) of the body of a human or animal so that a phrenic nerve (53; 536) of the body's neural system a human or animal can be reached by the target area (213; 2136, 2156) of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) of the field generator electromagnetic (21; 210; 217; 218; 219).
[16]
16. Electromagnetic induction device (2; 20; 27; 28), according to claim 15, CHARACTERIZED by the fact that the mounting arrangement (22; 220; 227; 228) comprises a liable arc member (2217) distance arrangement around the neck (52; 520; 527; 528) of the body of a human or animal, the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) is held in the arc member (2217) of the mounting arrangement.
[17]
17. Electromagnetic induction device (2; 20; 27; 28), according to claim 16, CHARACTERIZED by the fact that the arc member (2217) is equipped with an access passage.
[18]
18. Electromagnetic induction device (2; 20; 27; 28), according to any of the preceding claims, CHARACTERIZED by the fact that the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) is configured to automatically adjust a field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) and the calibration unit (31; 310; 38) is configured to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically vary the field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) and optionally
control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically stop the variation in the field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when activation feedback is received.
[19]
19. Electromagnetic induction device (2; 20; 27; 28), according to any of the preceding claims, CHARACTERIZED by the fact that the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) is configured to automatically adjust the temporal characteristics of the electromagnetic field (212; 2126, 2146) and the calibration unit (31; 310; 38) is configured to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically vary the temporal characteristics of the electromagnetic field (212; 2126, 2146) and, optionally, control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically stop the variation of the temporal characteristics of the electromagnetic field (212; 2126, 2146) generated by the coil project (211; 2110; 2117; 2118; 2119) when the activation feedback is received.
[20]
20. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that it comprises a tracker (23) configured to detect a movement of the body of a human or an animal in relation to the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) and to automatically change the position of the electromagnetic field (212; 2126, 2146) to compensate for the detected movement of the body of a human or animal in relation to the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219).
[21]
21. Electromagnetic induction device (2; 20; 27; 28), according to any of the preceding claims, CHARACTERIZED by the fact that it comprises an alarm unit, in which the tracker (23) is connected to the alarm unit and configured to activate the alarm unit when the detected movement exceeds an attainable compensation range by changing the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) through the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219).
[22]
22. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that the sensor member (4; 40; 48) comprises a pressure sensor having a connectable adapter to a respiratory system in the body of a human or animal, the pressure sensor being configured to detect a pressure change induced by a target tissue activity.
[23]
23. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that the calibration unit (31; 310; 38) is configured to control the electromagnetic field generator (21; 210; 217; 218; 219) to generate the electromagnetic field (212; 2126, 2146) in pulses while the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) is varied, and controlling the electromagnetic field generator (21; 210; 217; 218; 219) to generate the electromagnetic field (212; 2126, 2146) like a train when the position variation of the electromagnetic field (212 ; 2126, 2146) generated by the coil project (211; 2110; 2117; 2118; 2119) is stopped.
[24]
24. Electromagnetic induction device (2; 20; 27; 28), according to claim 23, CHARACTERIZED by the fact that the calibration unit (31; 310; 38) is configured to control the electromagnetic field generator (21 ; 210; 217; 218; 219) to generate the electromagnetic field (212; 2126, 2146) as a train with an initially lower field strength and then an increasing field strength in relation to the electromagnetic field (212; 2126, 2146) in pulses.
[25]
25. Electromagnetic induction device (2; 20; 27; 28), according to any of the preceding claims, CHARACTERIZED by the fact that the activation feedback signal comprises several activation responses of the target tissue each associated with a position specific to the target area (213; 2136, 2156) of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119), and the calibration unit (31; 310; 38) is configured to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to adjust the position of the target area (213; 2136, 2156) of the electromagnetic field (212; 2126, 2146) to the associated specific position to the strongest or most appropriate response among the various responses of the activation feedback signal, when the activation feedback signal is received.
[26]
26. Electromagnetic induction device (2; 20; 27; 28), according to any one of the preceding claims, CHARACTERIZED by the fact that the activation feedback signal comprises several activation responses of the target tissue each associated with a position specific to the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119), and the calibration unit (31; 310; 38) is configured to control the field adjustment mechanism electromagnetic (21; 210; 217; 218; 219) to adjust the position of the electromagnetic field (212; 2126, 2146) to the specific position associated with a more appropriate response characteristic among the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the temporal field characteristics to the specific position and timing adjustments associated with the most appropriate response among the various responses of the feedback signal. activation, when the activation feedback signal is received, and / or adjusting the time field characteristics to the specific position and timing adjustments associated with the most appropriate response among the various responses of the activation feedback information, when the feedback signal from activation is received.
[27]
27. Process for the manufacture of an electromagnetic induction device (2; 20; 27; 28) to activate a target tissue in a human or animal body through its muscular or neural system, which comprises assembling a generator electromagnetic field (21; 210; 217; 218; 219) with a coil design (211; 2110; 2117; 2118; 2119) configured to generate a spatial electromagnetic field (212; 2126, 2146) having a desired shape (213; 2136, 2156), a mounting arrangement (22; 220; 227; 228) that maintains the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219 ) in the body of a human or animal, and a sensor member (4; 40; 48) configured to detect an activation of the target tissue, to the electromagnetic induction device (2; 20; 27; 28), CHARACTERIZED by fact of setting up an electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) configured to automatically adjust the position of the electromagnetic field ethical (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119), and a calibration unit (31; 310; 38) in communication with the sensor member (4; 40; 48) and with the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219), to the electromagnetic induction device, and configure the calibration unit,
control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically vary the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) , receive an activation feedback signal from the sensor member (4; 40; 48) upon detecting the activation of the target tissue, and control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically stop the variation of the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when the activation feedback is received.
[28]
28. Process according to claim 27, CHARACTERIZED by the fact that it comprises providing the mounting arrangement (22; 220; 227; 228) with a repositioning structure (222; 2129, 2139) configured to automatically change a position of the project coil (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) in relation to the body of a human or animal while being held in the body of a human or an animal.
[29]
29. Process according to claim 28, CHARACTERIZED by the fact that it comprises providing the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) with the repositioning structure (222; 2129, 2139) of the arrangement assembly (22; 220; 227; 228) and configure the calibration unit (31; 310; 38) to automatically vary the position of the electromagnetic field (212; 2126, 2146) inducing the repositioning structure (222; 2129, 2139) to automatically change the position of the coil design (211; 2110; 2117; 2118; 2119) in relation to the body of a human or animal.
[30]
30. Process according to claim 28 or 29, CHARACTERIZED by the fact that it comprises providing the repositioning structure (222; 2129, 2139) of the mounting arrangement (22; 220; 227; 228) with a tilt mechanism such as joint configured to tilt the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) in relation to the body of a human or animal when being maintained in the body of a human or animal.
[31]
31. Process according to any one of claims 27 to 30, CHARACTERIZED in that it comprises providing the electromagnetic field generator (21; 210; 217; 218; 219) with a repositionable conductive element located in the electromagnetic field (212; 2126 , 2146) generated by the coil project.
[32]
32. Process according to claim 31, CHARACTERIZED by the fact that it comprises providing the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) with the conducting element of the electromagnetic field generator (21; 210; 217 ; 218; 219) and configure the calibration unit (31; 310; 38) to automatically vary the position of the electromagnetic field (212; 2126, 2146) by inducing the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically reposition the conductive element in the electromagnetic field.
[33]
33. Process according to claim 30 or 31, characterized by the fact that it comprises providing the conducting element with a conducting axis.
[34]
34. Process according to any one of claims 27 to 33, CHARACTERIZED in that it comprises providing the electromagnetic field generator (21; 210; 217; 218; 219) with a coil arrangement (211; 2110; 2117; 2118 ; 2119) which includes the coil design.
[35]
35. Process according to claim 34, CHARACTERIZED by the fact that it comprises providing the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) with the coil arrangement (211; 2110; 2117; 2118; 2119 ) of the electromagnetic field generator (21; 210; 217; 218; 219) and configure the calibration unit (31; 310; 38) to automatically vary the electromagnetic field (212; 2126, 2146) by inducing the adjustment mechanism electromagnetic field (21; 210;
217; 218; 219) to automatically enable different coil combinations of the coil arrangement.
[36]
36. Process according to claim 34 or 35, CHARACTERIZED by the fact that the coils (211; 2110; 2117; 2118; 2119) of the coil arrangement (211; 2110; 2117; 2118; 2119) overlap.
[37]
37. Process according to any one of claims 34 to 36, CHARACTERIZED by the fact that it comprises the arrangement of coils (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218 ; 219) to generate a plurality of electromagnetic fields each having a desired shape (213; 2136, 2156), the coil arrangement (211; 2110; 2117; 2118; 2119) being arranged so that the plurality of fields electromagnetic fields overlap and generate an accumulated intensity.
[38]
38. Process according to any of claims 27 to 37, CHARACTERIZED by the fact that it comprises providing the sensor member (4; 40; 48) with at least one electrode configured to be attached to the body of a human or a so that it captures an activity of the target tissue.
[39]
39. Process according to any one of claims 27 to 38, CHARACTERIZED in that it comprises providing the sensor member (4; 40; 48) with a flow sensor (41; 418) having an adapter connectable to a respiratory system of the body of a human or animal, and the flow sensor (41; 418) is configured to detect an airflow change induced by an activity of the target tissue.
[40]
40. Process according to claim 39, CHARACTERIZED by the fact that it comprises configuring the flow sensor adapter (41; 418) of the sensor member (4; 40; 48) to be connected to a mouth and / or a nose of the body of a human or animal.
[41]
41. Process according to any of claims 27 to 40,
CHARACTERIZED by the fact that it comprises configuring the mounting arrangement (22; 220; 227; 228) to maintain the coil design (211; 2110; 2117; 2118; 2119) on the neck (52; 520; 527; 528) of the body of a human or animal so that a phrenic nerve (53; 536) of the neural system of the body of a human or animal can be reached by the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219).
[42]
42. Process according to claim 41, CHARACTERIZED in that it comprises providing the mounting arrangement (22; 220; 227; 228) with an arc member capable of being arranged at a distance around the neck (52; 520; 527 ; 528) of the body of a human or animal, and the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) is maintained in the arc member of the mounting arrangement.
[43]
43. Process according to claim 42, CHARACTERIZED by the fact that the arch member is equipped with an access passage.
[44]
44. Process according to any one of claims 27 to 43, CHARACTERIZED by the fact that it comprises mounting a tracker on the electromagnetic induction device, in which the tracker is configured to detect movement of the body of a human or animal in relation to the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) and to automatically change the position of the electromagnetic field (212; 2126, 2146) to compensate for the detected movement of the body of a human or animal in relation to the coil design (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219).
[45]
45. Process according to any one of claims 27 to 44, CHARACTERIZED by the fact that it comprises configuring the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically adjust an electromagnetic field strength (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) and configure the calibration unit (31; 310; 38) to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically vary the field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) and control the electromagnetic field adjustment mechanism (21 ; 210; 217; 218; 219) to automatically stop the variation of the field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when the activation feedback is received.
[46]
46. Process according to any one of claims 27 to 45, CHARACTERIZED by the fact that it comprises mounting an alarm unit on the electromagnetic induction device, in which the tracker is connected to the alarm unit and configured to activate the alarm unit when the detected movement exceeds an attainable compensation range by changing the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) through the electromagnetic field adjustment mechanism ( 21; 210; 217; 218; 219).
[47]
47. Process according to any one of claims 27 to 46, CHARACTERIZED by the fact that it comprises configuring the calibration unit to control the electromagnetic field generator (21; 210; 217; 218; 219) to generate the electromagnetic field ( 212; 2126, 2146) in pulses while the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) is varied, and to control the electromagnetic field generator (21; 210; 217; 218; 219) to generate the electromagnetic field (212; 2126, 2146) as a train when the position variation of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) is stopped.
[48]
48. Process according to claim 47, CHARACTERIZED by the fact that it comprises configuring the calibration unit (31; 310; 38) to control the electromagnetic field generator (21; 210; 217; 218; 219) to generate the electromagnetic field (212; 2126, 2146) as a train with an initially lower field strength and then an increasing field strength in relation to the electromagnetic field (212; 2126, 2146) in pulses.
[49]
49. Process according to any one of claims 27 to 48, CHARACTERIZED by the fact that the activation feedback signal comprises several activation responses from the target tissue each associated with a specific position of the electromagnetic field (212; 2126, 2146 ) generated by the coil design (211; 2110; 2117; 2118; 2119), which comprises configuring the calibration unit (31; 310; 38) to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to adjust the position of the electromagnetic field (212; 2126, 2146) to the specific position associated with a more appropriate response characteristic of the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjust the time field characteristics to the specific position and time adjustments associated with a more appropriate response among the various responses of the activation feedback signal, when the feedback signal activation information is received, and / or adjust the time field characteristics to the specific position and time adjustments associated with the most appropriate response characteristic among the various responses of the activation feedback information, when the activation feedback information is received.
[50]
50. Process according to any one of claims 27 to 49, CHARACTERIZED by the fact that it comprises configuring the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically adjust the temporal characteristics of the electromagnetic field ( 212; 2126, 2146) and configure the calibration unit (31; 310; 38) to control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically vary the temporal characteristics of the electromagnetic field (212 ; 2126, 2146) and, optionally, control the electromagnetic field adjustment mechanism (21; 210; 217; 218; 219) to automatically stop the variation of the temporal characteristics of the electromagnetic field (212; 2126, 2146) generated by the project coil (211; 2110; 2117; 2118; 2119) when activation feedback is received.
[51]
51. Method for activating a target tissue in a human or animal body through its muscular or neural system, which comprises positioning the coil project (211; 2110; 2117; 2118; 2119) in the body of a human or animal, generate a spatial electromagnetic field (212; 2126, 2146) having a desired shape (213; 2136, 2156) through the coil design (211; 2110; 2117; 2118; 2119), and capture to activate the target tissue, CHARACTERIZED by the fact that it comprises adjusting a position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119), automatically varying the position of the electromagnetic field ( 212; 2126, 2146) generated by the coil project (211; 2110; 2117; 2118; 2119), evaluate the activation feedback obtained by the capture for activation of the target tissue, and automatically stop the variation of the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when activation is detected by uptake to activate the target tissue.
[52]
52. Method, according to claim 51, CHARACTERIZED by the fact that automatically varying the position of the electromagnetic field (212; 2126, 2146) comprises automatically changing the position of the coil design (211; 2110; 2117; 2118; 2119) in relation to the body of a human or animal.
[53]
53. Method, according to claim 51 or 52, CHARACTERIZED by the fact that automatically varying the position of the electromagnetic field (212; 2126, 2146) comprises automatically repositioning a conductive element in the electromagnetic field.
[54]
54. Method according to any one of claims 51 to 53, CHARACTERIZED by the fact that the electromagnetic field generator (21; 210; 217; 218; 219) comprises an array of coils (211; 2110; 2117; 2118; 2119) including the coil design.
[55]
55. Method, according to claim 54, CHARACTERIZED by the fact that automatically varying the position of the electromagnetic field (212; 2126, 2146) comprises automatically enabling different coil combinations of the coil arrangement.
[56]
56. Method according to claim 54 or 55, CHARACTERIZED by the fact that the coils (211; 2110; 2117; 2118; 2119) of the coil arrangement (211; 2110; 2117; 2118; 2119) overlap.
[57]
57. Method, according to claims 54 to 56, CHARACTERIZED by the fact that the coil arrangement (211; 2110; 2117; 2118; 2119) of the electromagnetic field generator (21; 210; 217; 218; 219) is arranged to generate a plurality of spatial electromagnetic fields having a desired shape (213; 2136, 2156), the coil arrangement (211; 2110; 2117; 2118; 2119) being arranged so that the plurality of electromagnetic fields overlap and generate an accumulated intensity.
[58]
58. Method according to any one of claims 51 to 57, CHARACTERIZED by the fact that the capture for activation of the target tissue comprises attaching at least one electrode to the body of a human or animal.
[59]
59. Method according to any one of claims 51 to 58, CHARACTERIZED by the fact that the capture for activation of the target tissue comprises connecting a flow sensor (41; 418) to a respiratory system in the body of a human being or of an animal, and detect an airflow change induced by a target tissue activity.
[60]
60. Method according to claim 59, CHARACTERIZED by the fact that the flow sensor (41; 418) is connected to a mouth and / or a nose on the body of a human or animal.
[61]
61. Method according to any one of claims 51 to 60, CHARACTERIZED by the fact that positioning the coil design (211; 2110; 2117; 2118; 2119) in the body of a human or animal comprises maintaining the design coil (211; 2110; 2117; 2118; 2119) on a neck (52; 520; 527; 528) of the body of a human or animal so that a phrenic nerve (53; 536) of the neural system of the The body of a human or animal can be reached by the electromagnetic field (212; 2126, 2146) generated by the coil design.
[62]
62. Method according to any one of claims 51 to 61, CHARACTERIZED by the fact that it comprises automatically adjusting a field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118 ; 2119), automatically vary the field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) and stop the variation of the field strength of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when an activation of the target tissue is captured.
[63]
63. Method according to any of claims 51 to 62, CHARACTERIZED by the fact that it comprises generating the electromagnetic field
(212; 2126, 2146) in pulses while the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) is varied, and generate the electromagnetic field (212; 2126 , 2146) as a train when the variation in the position of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) is stopped.
[64]
64. Method, according to claim 63, CHARACTERIZED by the fact that it comprises generating the electromagnetic field (212; 2126, 2146) as a train with an initially lower field strength and then an increasing field strength in relation to the electromagnetic field (212; 2126, 2146) in pulses.
[65]
65. Method according to any of claims 51 to 64, CHARACTERIZED by the fact that the activation feedback signal comprises several activation responses from the target tissue each associated with a specific position of the target area (213; 2136, 2156 ) of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119), and the position of the electromagnetic field (212; 2126, 2146) is adjusted to the specific position associated with a characteristic most appropriate response of the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjusting the temporal field characteristics to the specific position and timing adjustments associated with the most appropriate response among the various responses of the activation feedback signal, when the activation feedback signal is received, and / or adjust the temporal field characteristics to the specific position and temporal adjustments as associated with the most appropriate response characteristic among the various responses of the activation feedback signal, when the activation feedback signal is received.
[66]
66. Method according to any one of claims 51 to 65, CHARACTERIZED by the fact that it comprises adjusting the temporal characteristics of the electromagnetic field (212; 2126, 2146) and varying the temporal characteristics of the electromagnetic field (212; 2126, 2146) and, optionally, stop the variation of the temporal characteristics of the electromagnetic field (212; 2126, 2146) generated by the coil design (211; 2110; 2117; 2118; 2119) when the activation feedback is received.
[67]
67. Use of an electromagnetic induction device (2; 20; 27; 28), as defined in any one of claims 1 to 26, CHARACTERIZED by the fact that it serves for transcutaneous electromagnetic induction of a phrenic nerve (53; 536) for a diagnostic purpose to assess diaphragm function, or sleep apnea, or other forms of breathing for sleep disorders.
[68]
68. Use of an electromagnetic induction device (2; 20; 27; 28), as defined in any one of claims 1 to 26, CHARACTERIZED by the fact that it serves for regular repetitive transcutaneous electromagnetic induction of a phrenic nerve (53; 536 ) for therapeutic use in patients without spontaneous breathing, for example, for resuscitation and to keep alive patients who do not have the function of a respiratory center.
[69]
69. Use of an electromagnetic induction device (2; 20; 27; 28), as defined in any one of claims 1 to 26, CHARACTERIZED by the fact that it serves for repeated transcutaneous electromagnetic induction of a phrenic nerve (53; 536) for therapeutic use in patients without spontaneous contractions of the diaphragm, or with insufficient spontaneous contractions of the diaphragm, who have at least one phrenic nerve (53; 536) partially intact.

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WO2021074455A1|2019-10-18|2021-04-22|Stimit Ag|Stimulation device and use thereof|

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WO2021074453A1|2019-10-18|2021-04-22|Stimit Ag|Respiration promoting apparatus and use thereof|

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WO2021123452A1|2019-12-19|2021-06-24|Stimit Ag|Ventilation arrangement and treatment method|

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WO2021204981A1|2020-04-09|2021-10-14|Stimit Ag|Stimulation arrangement and method of activating a patient|

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WO2021204982A1|2020-04-09|2021-10-14|Stimit Ag|Stimulation arrangement and mothod of operating such stimulation arrangement|

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WO2021239523A1|2020-05-18|2021-12-02|Stimit Ag|Respiration promoting apparatus and use thereof|

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WO2022018231A1|2020-07-22|2022-01-27|Stimit Ag|Stimulation arrangements, ventilation arrangement, stimulation methods and ventilation method|

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RU2738769C1|2020-09-15|2020-12-16|федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации|Artificial lung ventilation apparatus|

法律状态:
2021-12-07| B350| Update of information on the portal [chapter 15.35 patent gazette]|

优先权:

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申请号 | 申请日 | 专利标题

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CH1352018|2018-02-06|

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CH00135/18|2018-02-06|

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CH7332018|2018-06-07|

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CH00733/18|2018-06-07|

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PCT/EP2019/052876|WO2019154837A1|2018-02-06|2019-02-06|Electro-magnetic induction device and method of activating a target tissue|

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